COMPOSITION

Each capsule contains vincamine 30 mg.

THERAPEUTIC INDICATONS

For normalization and adaptation of cerebral circulation for metabolic needs of brain cord, for regulation, improving and supporting its functions.
- Hypomnesia;
- Clouded sensorium disorders;
- Diabetic angiopathy;
- Cerebral atherosclerosis;
- Conditions after craniocerebral trauma and acute cerebrovascular accident;
- Brain damages following ischemia;
- Hypertensive encephalopathy;
- Hearing and vision disorders with vascular genesis;
- Disorientation in place and time.

CONTRAINDICATIONS

- Brain tumor;
- Pregnancy and lactation;
- Known increased sensitivity to vinkamin and other components of preparation.

ADVERSE EFFECTS

Digestion system: sickness, vomiting, epigastric burning, diarrhea, constipation, dry mouth.
Cardio-vascular system: decrease of ABP, tachycardia.
Allergic reactions: skin rash, itching.

DOSAGE AND ADMINISTRATION

Vinebral capsules are taken orally with enough amount of water.
In adults 1 capsule is taken 2 times per day. The treatment duration depends on the disease progress and is established by a doctor.

DRUG INTERACTIONS

Concominant administration of Vinebral with itraconasole and vinkristin can increase neurotoxicity with acute lymphoblastic leukemia.
Vinebral potentiates antihypertensive agents and antiaggregants. Combination of kinupristin/dalfopristin acts as inhibitor isoenzyme CYP3A4 and in case of concominant administration can increase consentration of vinkamin in blood plasma.

MANUFACTURED FORM

Hard gelatin capsule with sustained release.
10 capsules in blister. 2 blisters in carton box with enclosed leaflet.