Secnidox
(Secnidazole)




COMPOSITION

Each tablet contains secnidazole 1.0 g.

THERAPEUTIC INDICATIONS

- Mycotic urethritis and vaginitis (caused by Trichomonas vaginalis);
- Bacterial vaginosis;
- Amebiasis of intestine (caused by Еntamoeba histolytica);
- Amebiasis of liver (caused by Еntamoeba histolytica);
- Lambliosis (caused by Giardia lamblia).

CONTRAINDICATIONS

- Hypersensitivity to secnidazole and to other derivatives of imidazole;
- Organic CNS diseases;
- Pregnancy and the period of lactation.

ADVERSE EFFECTS

From digestive system: infringements of digestion, nausea, pains in the field of stomach, "metal" smack in a mouth, glossitis, stomatitis. From system hematosis: moderate reversible leukopenia. Allergic reactions: hives.

DOSAGE AND ADMINISTRATION

Secnidox is administered orally directly before the meal, drinking after a small amount of water.
Doses for adults:
Mycotic urethritis and vaginitis, bacterial vaginosis: 2 tablets at once.
Amebiasis of intestine:
- Acute symptomatic amebiasis: 2 tablets at once.
- Asymptomatic amebiasis, including focal and cystitis forms: 2 tablets at once daily during 3 days.
Amebiasis of liver: daily 1,5 tablets (1,5g) once or in separate doses during 5 days.
Doses for children:
Amebiasis of intestine:
- Acute symptomatic amebiasis: 30 mg/kg of body weight once.
- Asymptomatic amebiasis, including focal and cystitis forms: once a day or separate administration of the preparation in a dose of 30 mg/kg of body weight during 3 days.
Amebiasis of liver: once a day or separate administration of the preparation in a dose of 30 mg/kg of body weight during 5 days.
Lambliosis: 30 mg/kg of body weight once.

DRUG INTERACTIONS

Secnidox at simultaneous application strengthens the action of indirect anticoagulants (derivatives of coumarin or indandione).
Simultaneous administration of Secnidox with disulfiram can cause paranoiac reactions and psychoses. In combination with alcohol causes the symptoms of disulfiramlike reaction (spasms in stomach, nausea, vomiting, headache, rush of blood to the face).
Secnidox at simultaneous application with preparations of lithium increases its concentration in blood plasma.
The preparation is not recommended to be combined with nondepolarizing muscle relaxant (vecuronium bromide).
In combination with amoxicillin increases the activity concerning Helicobacter pylori (amoxicillin suppresses development of resistance).

MANUFACTURED FORM

2 film coated tablets in blister. 1 blister in carton box with enclosed leaflet.

Antiparasitic Products

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Helmadol
Helmadol
Secnidox

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