Doprokin-S (Domperidone)
COMPOSITION
Each 5 ml of suspension contain 5 mg of
domperidone and 20 mg of simethicone.
THERAPEUTIC INDICATIONS
- The sense of overfilling in epigastria,
abdominal distension and bowels swilling, pain in upper part of a stomach.
- Eructation, meteorism.
- Nausea, vomiting.
- Pyrosis with or without reflux.
- Excessive gas-formation in postoperative period.
Preparation for gastroduodenoscopy, x-ray and instrumented abdominal and pelvic
examination.
CONTRAINDICATIONS
Doprokin-S suspension is contraindicated for
patients with known hypersensitivity to any drug compounds. Doprokin-S
suspension should not be administered in case of gastrointestinal bleeding,
mechanical bowel obstruction or perforation.
ADVERSE EFFECTS
Allergic reactions, such as skin rash and itching
have been seldom reported. Extrapyramidal effects have been seldom observed in
children and are not typical for adults. These effects are completely reversible
and spontaneously disappear after the treatment cessation. The potential onset
of neurological adverse effects cannot be completely excluded in case of
insufficient development of blood-brain barrier (i.e. in children) or its
dysfunction.
DOSAGE AND ADMINISTRATION
The recommended dose of Doprokin-S suspension for
adults is 10-20 ml every 4-8 hours and for children is 5-10 ml every 4-8 hours.
Doprokin-S suspension is prescribed 15-30 minutes before meal.
DRUG INTERACTIONS
Anticholinergic drugs can neutralize an
antidyspeptic action of Doprokin-S suspension. Do not -administer antacid and
antisecretory agents with Doprokin-S suspension as they decrease bioavailability
of Domperidone following oral administration.
PREGNANCY AND LACTATION
Domperidone does not demonstrate a teratogenic
action. Doprokin-S suspension should be administered during pregnancy only if
the expected benefit justifies the potential risk to the fetus.
Domperidone concentration in human milk is 4 times less than the corresponding
plasma concentrations. It is not known if this level takes a negative effect on
infants. Therefore if a nursering mother administers Doprokin-S suspension,
breast-feeding is not recommended, taking into account the importance of the
drug to mother.
MANUFACTURED FORM
Suspension 60 ml in vials with a volumetric cap.
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